The association of asthma, nasal polyp disease and exacerbation of respiratory disease by aspirin, was reported by Samter and Beers in the 1960's and has been known since as Samter's triad. The association of aspirin and the other non-steroidal anti-inflammatory drugs, including Aleve (naproxen) and Advil (ibuprofen), with respiratory disease is now also known as aspirin-associated respiratory disease, or AERD. Typical features are nasal polyp disease, nasal and ocular congestion, asthma, tendency to flushing and hives, and a history of asthma exacerbation by one of the non-steroidal anti-inflammatory drugs (NSAIDs). The NSAIDs prevent inflammation because they inhibit an enzyme called COX-1. This enzyme produces chemicals that perpetuate inflammation, such as arthritis. It is thought that the respiratory effects of these drugs occur because, in blocking the COX-1 enzyme, chemicals that would be made in the COX-1 pathway are no longer produced. Those chemicals in turn would ordinarily ...Click here to view the full reply on Net Wellness.
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